Absorption through scarred, thickened tissue becomes erratic and unpredictable , so the same drawn dose can behave inconsistently
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PMC 7386876
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Yet this compelling mechanistic story has generated precisely zero human clinical trials for mental health applications
Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times